Chemicalsat.com ECP Ltd New Zealand
   
 
 

ROMIL-SpS™ Super Purity Solvents - high purity solvents for instrumental analysis

   
  Romil Main page

See below for  SpS ready made HPLC eluant mixtures

  For specifications SEARCH   individual products

 

 

 


 Romil SpS - Super Purity Solvents :-The Analytical Grade for the Third Millennium

 

Sp S pic

Reduce inventory!! ACS grade reagent and for HPLC,GC, Pesticide residue analysis and UV spectroscopy.  ...“the laboratory user can take advantage not only of the consistent quality of ROMIL-SpS™, but also its suitability for a wide range of applications. And since one grade only need be stocked for a variety of methods, ROMIL-SpS™ products also have the benefit of assisting laboratories, not only in their compliance with health, safety and environmental legislation, but also in their quality system accreditation to international standards such as ISO 9000 and ISO 17025.”

It is easy to understand why the vast majority of chemical experiments are conducted in the liquid phase. Solids rarely react together and gases are too difficult to contain. This is especially true of analytical chemistry where the analyte to be measured is first processed into a more manageable and convenient form - a solution - before being presented to the measurement process. This process can be as simple as a manual titration or as complicated as a modern hyphenated separation-detection technique.

Modern analytical chemistry makes extensive use of sophisticated instrumentation. For analysis at the parts per billion level, this usually is the only choice. However, for such instrumentation to perform consistently and reliably the analyst should choose his solvent system very carefully.

Often the solvent is the key factor in obtaining a valid analytical measurement. Solvent effects such as polarity and dipole moment can affect how the analyte can be brought into solution in the first place. Properties such as boiling point and melting point can determine the ease with which the analyte solution can be handled. And the purity of the solvent can be a critical factor in detecting and measuring the analyte because solvent impurities can either mask the analyte peak as in chromatography, or suppress its presence by poor transparency as in ultra-violet or infra-red spectroscopy.

Many suppliers of laboratory chemicals have responded by supplying higher purity solvents and reagents specifically branded for a particular instrumental technique. The now ubiquitous 'HPLC solvent' or 'spectroscopy solvent' are typical examples. And this because their own so-called 'analytical grade' products are just not good enough for modern analysis! This is because, generally, most laboratory suppliers are no more than that. That is, they supply laboratory chemicals; they don't manufacture them. The chemicals themselves are actually manufactured by the global chemical industry. The laboratory suppliers buy from these sources, perhaps test for suitability, then package into smaller containers and offer to the laboratory user. With the laboratory sector accounting for an insignificant fraction of their output, it is clear that the multi-national manufacturers are just not interested in producing chemicals with the laboratory user in mind. When their production plants must be cleaned out or spent catalyst replaced, the negative effect on the product quality is not noticed by their industrial customers. But, this can have a profound influence on the quality of such solvent when used in the laboratory.

ROMIL-SpS™ Super Purity Solvents have long addressed this problem. By taking the solvent output from prime global sources and purifying it by chemical treatment and glass distillation we both remove this inconsistent quality as well as making a vast improvement to the purity (or, to look at it another way, a vast reduction in impurities). This means that the laboratory user can take advantage not only of the consistent quality of ROMIL-SpS™, but also its suitability for a wide range of applications. And since one grade only need be stocked for a variety of methods, ROMIL-SpS™ products also have the benefit of assisting laboratories, not only in their compliance with health, safety and environmental legislation, but also in their quality system accreditation to international standards such as ISO 9000 and ISO 17025. They truly are to be considered the de facto analytical grade for laboratories in the third millennium.

   See also SpR Ion pair reagents and buffers

  Key Applications Overview for Super Purity Solvents

   
 
High Performance Liquid Chromatography
High chemical purity together with low water, acidity and residue levels lead to better separations and longer column life with ROMIL-SpS™ solvents. Excellent optical purity at low wavelengths leads to improved detector sensitivity in the far ultra-violet region.

GC, Capillary GC and Pesticide Residue Analysis
Low non-volatile residue levels due to glass distillation make ROMIL-SpS™ solvents suitable for simple analysis of pesticide and other extraction residues. The solvent may be concentrated by evaporation and will be free from interfering chromatographic signals with flame ionisation and electron capture detectors.
Test for Pesticide Residue Analysis:
The solvent is evaporated to dryness and the residue dissolved in high purity 2,2,4-trimethylpentane. A gas chromatogram is then run with ECD detection to determine no interfering peaks greater in area than that obtained by 5 ng/LT lindane (in the neat solvent) within the range of retention times from lindane (shortest) to 4,4’-DDT (longest).

Ultra-Violet Spectroscopy
Excellent optical purity with a smooth spectral curve renders ROMIL-SpS™ solvents suitable for all UV applications. For work at short wavelengths we recommend that the solvent is nitrogen purged before use and that partially used solvents are stored under an inert atmosphere.
Test for Ultra-Violet Spectroscopy:
The solvent is first purged with dry nitrogen for 5-10 minutes. UV Transmission values are then measured in a 10mm quartz cell using ROMIL Code H950 Water SpS as reference.

Infra-Red Spectroscopy
Clear infra-red windows in many ROMIL-SpS™ solvents give a wide choice of suitable solvents. To aid the analyst in selection a typical spectrum of any solvent is available on request.
Test for Infra-Red Spectroscopy:
An infra-red spectrum is matched against that of a reference standard to check for identity and to verify the absence of uncharacteristic absortion bands.

Fluorescence Spectroscopy
A very low fluorescence background makes ROMIL-SpS™ solvents suitable for this useful technique as well as fluorescence detection in HPLC.
Test for Fluorescence Spectroscopy:
Fluorescence background is less than that given by a 2 ppb solution of quinine.

Non-aqueous Titrations
Both volumetric and coulometric techniques are catered for by the very low water levels in ROMIL-SpS™ solvents. Also suitable for electrochemical detection in HPLC. See also our range of ROMIL Hi-Dry® Karl Fischer reagents and anhydrous solvents which take the concept of dryness and its determination one stage further.

Trace Element Analysis
Metallic impurities in ROMIL-SpS™ solvents are typically in the parts per billion range making them suitable for a wide variety of trace metal applications including the increasingly important area of environmental monitoring. Typical uncontrolled elemental impurity levels at time of manufacture are given for a number of solvents. Note that concentrations of some elements, particularly Ca, Si, K, Na, B, Al, Mg, Mn will increase over time due to storage in glass bottles.

Combinatorial Chemistry and Organic Synthesis
In combinatorial chemistry large numbers of compounds are rapidly synthesised in minute quantities for screening for biological or catalytic activity. Solvent impurities can produce erroneous results and make difficult the identification of new leads. ROMIL-SpS™ solvents, being chemically pure, thus facilitate the efficient interpretation of combinatorial libraries. Furthermore, many organic and organometallic synthetic methods specify a dry solvent as the reaction medium. The exceptional dryness exhibited by ROMIL-SpS™ solvents allows synthetic chemists to avoid the hazardous and time-consuming drying of solvents in the laboratory prior to use. See also the ROMIL Hi-Dry® anhydrous solvents that feature even lower water levels.

Liquid Scintillation Counting
Cocktails may be made with confidence since the relevant ROMIL-SpS™ solvents feature low quenching impurities and exhibit low background counts due to manufacture from petrochemical feedstocks.

Molecular Biology
Although many ROMIL-SpS™ solvents are suitable for use in molecular biology we have found that the purity constraints can be different for this area of science. To answer the specific needs of biochemists and molecular biologists we have available a number of solvents available as a separate ROMIL-BiO™ grade detailed in a separate section.

 
Romil  

SpS™ Super Purity Solvent Mixes
HPLC Eluants & GC Extraction & Calibration mixes

   
 
Consistent Product Performance

Rarely are solvents used on their own in the laboratory. Invariably, they're used to bring into solution the sample to be analysed or the reactants to be reacted together. Also, many solvents themselves are used as mixtures, for example as eluants in HPLC or as extraction and reference mixtures in GC.

ROMIL have long provided an optional service whereby ready-to-use solvent mixtures are made up to customer specifications. Such a service finds favour in routine QC where methods are established on defined mixtures and which must be made in large volumes.

HPLC Eluants Mixtures are made from our ROMIL-SpS™ and similar materials thus ensuring a consistent performance. For example, HPLC eluants are often made up with commercial solvents combined with in-house produced water. Without sufficient in-house control on the quality of this water, the performance of the whole mixture is impaired.

In our experience reagent quality should be matched across the individual components of a mixture. Otherwise, the quality degenerates to the least pure constituent. This is often the case of HPLC eluants where the quality of the in-house produced water is not sufficiently controlled to maintain the quality of the mixture and this can result in time wasting chasing of ghost peaks and complaints to the supplier of the solvent. That is not to say that commercial laboratory water purifiers cannot produce the highest quality water. They can. But to do that reliably not only requires the investment in the purification equipment itself, but also an on-going system of regular maintenance and strict quality control of the output.

Sourcing your HPLC eluants from ROMIL ensures consistency of product performance and also reduces costs which are otherwise incurred in the handling of hazardous solvents in the QC laboratory.

GC Calibration mixes Again, in the QC laboratory extensive use may be made of proprietary solvent mixes as reference materials in GC analysis of product quality in chemical and pharmaceutical production. Indeed, the regular ROMIL-SpS™ solvents themselves may be used as reliable and cost effective reference materials for gas chromatography, being generally specified to a minimum 99.9% purity and available in convenient 500ml packs.

Mixtures may be made up from ROMIL-SpS™ solvents using balances calibrated with weights traceable to the internationally recognised SI units. So in many respects it can be advantageous to out-source the production of such materials to an organisation such as ROMIL which has both the required expertise as well as direct access to and control of the pure components.

Custom Mixes Ask for a quotation for your own specific mixture. Just give us the following information:
 
  • Detailed recipe (including concentration tolerances of ingredients)
  • Grades of solvent required (see SpS solvents section)
  • Preferred pack size (choose amber glass bottles or returnable stainless steel flasks)
  • Annual quantity / quantity per order (the larger the quantity, the lower the price)
email: Info@chemicalsat.com Let ROMIL save you time and money in making up these complex mixtures.